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ABSTRACT Ovarian steroid cell tumors are rare, representing less than 0.1% of all ovarian neoplasms. Among the myriad causes of hirsutism, ovarian tumors account for 1% of the reported cases. We present the case of a 49-year-old parous postmenopausal woman who sought medical attention for hirsutism for 2 years. This case illustrates the unusual and interesting connection between rare ovarian pathology and the clinical manifestation of hirsutism in a postmenopausal patient. Her ultrasonography and MRI showed a right adnexal mass of solid-cystic consistency with thin septations. Her laboratory workup revealed high levels of total testosterone of 256 ng/ml (8.4-48.1ng/ml) and free testosterone of 7.36 pg/ml (0.2-4.1 pg/ml), while DHEAS - 234 µg/dl (35.4-256 µg/dl) and CA125 - 15.8U/L (0.0-35 U/L) were in the normal range. She underwent exploratory laparotomy with a total abdominal hysterectomy and oophorectomy. Histopathological examination and immunohistochemistry conclusively established the presence of a steroid cell tumor, specifically classified as "Not Otherwise Specified"(NOS), in the right ovary.
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Abstract We present a case of a late preterm intrauterine growth-restricted neonate with isolated and persistent severe thrombocytopenia. At birth, the neonate did not have a complete clinical spectrum of congenital rubella syndrome (CRS) but later developed peculiar findings that helped clinch the diagnosis. The neonate also had interstitial pneumonia and died secondary to superimposed acute viral infection leading to acute respiratory distress syndrome. The serology was positive for IgM antibodies against the rubella virus. The constellation of clinical manifestations of congenital rubella in the presence of positive IgM antibody against rubella and consistent histopathology confirmed the diagnosis of CRS.
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Plant interactions with biotic and abiotic stresses are complex and entail changes at the transcriptional, cellularand physiological level. MicroRNAs (miRNAs) are small (*20–24 nt), non-coding RNAs that play a vital rolein wide range of biological processes involved in regulation of gene expression through translation inhibitionor degradation of their target mRNAs during stress conditions. Therefore, identification of miRNAs and theirtargets are of immense value in understanding the regulatory networks triggered during stress. Advancement incomputational approaches has opened up ways for the prediction of miRNAs and their possible targets withfunctional pathways. Our objective was to identify miRNA and their potential targets involved in both bioticand abiotic stresses in maize. A total of 2,019,524 downloaded ESTs from dbEST were processed and trimmedby Seq Clean. The program trashed 264,000 and trimmed 284,979 sequences and the resulting 1,755,534sequences were submitted for clustering and assembled to RepeatMasker and TGICL. A total of 30 miRNAswere found to hybridize with the potential targets of gene families such as CoA ligase, lipoxygenase 1,Terpenoideyclases, Zn finger, transducing, etc. Ten of the identified miRNAs targeted cytochrome c1 family.Zm_miR23 class targeted 11 different genes. The identified targets are involved in the plant growth anddevelopment during biotic and abiotic stresses in maize. These miRNAs may be further used for functionalanalysis. Furthermore, four and two of the miRNA targets were validated in response to waterlogging toleranceand southern leaf blight resistance, respectively, to understand the miRNA-assisted regulation of targetmiRNAs. The functional annotation of the predicted targets indicated that these stress-responsive miRNAsregulate cellular function; molecular function and biological process in maize at the post-transcriptional level.The present results have paved way towards better understanding the role of miRNAs in the mechanism ofstress tolerance in maize.